PT  - JOURNAL ARTICLE
AU  - TAKAHIRO TOYOKAWA
AU  - TATSURO TAMURA
AU  - KATSUNOBU SAKURAI
AU  - NAOSHI KUBO
AU  - HIROAKI TANAKA
AU  - KAZUYA MUGURUMA
AU  - MASAKAZU YASHIRO
AU  - MASAICHI OHIRA
TI  - Postoperative Inflammation Is an Independent Prognostic Factor in Patients With Thoracic Esophageal Squamous Cell Carcinoma
AID  - 10.21873/anticanres.13404
DP  - 2019 Jun 01
TA  - Anticancer Research
PG  - 2777--2784
VI  - 39
IP  - 6
4099  - http://ar.iiarjournals.org/content/39/6/2777.short
4100  - http://ar.iiarjournals.org/content/39/6/2777.full
SO  - Anticancer Res2019 Jun 01; 39
AB  - Background: The aim of this study was to elucidate the impact of postoperative inflammatory response on prognosis in patients with stage I thoracic esophageal squamous cell carcinoma (ESCC). Materials and Methods: Seventy-five consecutive patients who underwent subtotal esophagectomy for clinical stage I thoracic ESCC were reviewed retrospectively. Maximum serum CRP level (CRPmax) and white blood celI count (WBCmax) were evaluated as postoperative inflammatory parameters. Prognostic factors were analyzed using Cox proportional hazards modeling. Results: Optimal cut-off values were 10.7 mg/dl for CRPmax and 19,700/mm3 for WBCmax. On univariate analyses, older age, worse performance status, higher WBCmax, and infectious complications were significantly associated with poorer overall survival. Multivariate analysis revealed WBCmax >19,700/mm3 to be an independent prognostic factor for poorer overall survival (hazard ratio=3.356; 95% confidence interval=1.221-9.220; p=0.019). Conclusion: A high WBCmax in the early postoperative phase, but not infectious complications, was an independent prognostic factor for poor overall survival in patients with clinical stage I thoracic ESCC.