PT - JOURNAL ARTICLE AU - CARLOTTA PALUMBO AU - MARIA FURLAN AU - PIERA BALZARINI AU - TIZIANO ZANOTELLI AU - ALBERTO COZZOLI AU - ALESSANDRO VECCIA AU - SIMONE FRANCAVILLA AU - STEFANIA ZAMBONI AU - REGINA TARDANICO AU - CLAUDIO SIMEONE AU - ALESSANDRO ANTONELLI TI - Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma AID - 10.21873/anticanres.13402 DP - 2019 Jun 01 TA - Anticancer Research PG - 2757--2765 VI - 39 IP - 6 4099 - http://ar.iiarjournals.org/content/39/6/2757.short 4100 - http://ar.iiarjournals.org/content/39/6/2757.full SO - Anticancer Res2019 Jun 01; 39 AB - Background/Aim: Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up. Materials and Methods: A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan–Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS). Results: Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18. Conclusion: Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.