TY - JOUR T1 - Serum Prognostic Factors of Androgen-deprivation Therapy Among Japanese Men With <em>De Novo</em> Metastatic Prostate Cancer JF - Anticancer Research JO - Anticancer Res SP - 3191 LP - 3195 DO - 10.21873/anticanres.13457 VL - 39 IS - 6 AU - TAKESHI KOBAYASHI AU - RYO NAMITOME AU - YU HIRATA AU - MASAKI SHIOTA AU - KENJIRO IMADA AU - EIJI KASHIWAGI AU - ARIO TAKEUCHI AU - JUNICHI INOKUCHI AU - KATSUNORI TATSUGAMI AU - MASATOSHI ETO Y1 - 2019/06/01 UR - http://ar.iiarjournals.org/content/39/6/3191.abstract N2 - Background/Aim: To date, several serum prognostic factors have been reported in metastatic prostate cancer. In this study, we examined the prognostic value of these serum markers in Japanese men. Patients and Methods: This study included 104 patients with metastatic prostate cancer who were treated with primary androgen-deprivation therapy from 2001 to 2013. Clinicopathological factors including several serum markers were investigated for association with progression-free (PFS) and overall (OS) survival. Results: During a median follow-up of 48.1 months, median PFS and OS were 24.0 months and 67.4 months, respectively. When adjusted by age, prostate-specific antigen at diagnosis, Gleason score, and clinical stage, serum lactate dehydrogenase value was significantly associated with PFS [hazard ratio (HR)=1.42, 95% confidence interval (CI)=1.15-1.74; p=0.0004] and OS (HR=1.46, 95% CI=1.13-1.82; p=0.0014), in addition to alkaline phosphatase value for OS (HR=1.04; 95% CI=1.00-1.07; p=0.015). Conclusion: This study demonstrates the prognostic significance of alkaline phosphatase and lactate dehydrogenase values in Japanese men with de novo metastatic hormone-sensitive prostate cancer. ER -