RT Journal Article
SR Electronic
T1 Predictive Factors for Elevated Postoperative Carbohydrate Antigen 19-9 Levels in Patients With Resected Pancreatic Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3177
OP 3183
DO 10.21873/anticanres.13455
VO 39
IS 6
A1 TAKAGI, CHISATO
A1 KIKUCHI, YUTARO
A1 SHIRAKAWA, HIROFUMI
A1 HOSHIMOTO, SOJUN
A1 TOMIKAWA, MORIAKI
A1 OZAWA, IWAO
A1 HISHINUMA, SHOICHI
A1 OGATA, YOSHIRO
YR 2019
UL http://ar.iiarjournals.org/content/39/6/3177.abstract
AB Aim: In this study, we investigated the clinical significance of postoperative serum carbohydrate antigen (CA) 19-9 in patients with pancreatic ductal carcinoma (PDAC). Patients and Methods: A series of 116 patients with macroscopically curative PDAC resection was retrospectively evaluated. The cut-off level for elevated postoperative CA 19-9 was 37 U/ml. Results: Patients with high postoperative CA19-9 levels had a significantly poorer prognosis than patients with normal postoperative CA19-9 levels, as revealed by the log-rank test. Multivariate analysis identified R1 resection and preoperative serum CA19-9 level ≥400 U/ml independently predicted elevated postoperative CA 19-9 levels. R1 resection and preoperative serum CA19-9 ≥400 U/ml were significantly associated with the recurrence of peritoneal dissemination and hepatic metastasis, respectively, within one year of operation. Conclusion: Elevated postoperative serum CA 19-9 level was associated with a poor prognosis and reflected positive resection margins and high preoperative CA 19-9 levels, which indicated presence of occult distant metastasis in patients with PDAC.