PT  - JOURNAL ARTICLE
AU  - TAKAGI, CHISATO
AU  - KIKUCHI, YUTARO
AU  - SHIRAKAWA, HIROFUMI
AU  - HOSHIMOTO, SOJUN
AU  - TOMIKAWA, MORIAKI
AU  - OZAWA, IWAO
AU  - HISHINUMA, SHOICHI
AU  - OGATA, YOSHIRO
TI  - Predictive Factors for Elevated Postoperative Carbohydrate Antigen 19-9 Levels in Patients With Resected Pancreatic Cancer
AID  - 10.21873/anticanres.13455
DP  - 2019 Jun 01
TA  - Anticancer Research
PG  - 3177--3183
VI  - 39
IP  - 6
4099  - http://ar.iiarjournals.org/content/39/6/3177.short
4100  - http://ar.iiarjournals.org/content/39/6/3177.full
SO  - Anticancer Res2019 Jun 01; 39
AB  - Aim: In this study, we investigated the clinical significance of postoperative serum carbohydrate antigen (CA) 19-9 in patients with pancreatic ductal carcinoma (PDAC). Patients and Methods: A series of 116 patients with macroscopically curative PDAC resection was retrospectively evaluated. The cut-off level for elevated postoperative CA 19-9 was 37 U/ml. Results: Patients with high postoperative CA19-9 levels had a significantly poorer prognosis than patients with normal postoperative CA19-9 levels, as revealed by the log-rank test. Multivariate analysis identified R1 resection and preoperative serum CA19-9 level ≥400 U/ml independently predicted elevated postoperative CA 19-9 levels. R1 resection and preoperative serum CA19-9 ≥400 U/ml were significantly associated with the recurrence of peritoneal dissemination and hepatic metastasis, respectively, within one year of operation. Conclusion: Elevated postoperative serum CA 19-9 level was associated with a poor prognosis and reflected positive resection margins and high preoperative CA 19-9 levels, which indicated presence of occult distant metastasis in patients with PDAC.