RT Journal Article SR Electronic T1 Prognostic Impact of Proximal Versus Distal Localization in Extremity Long Bone Osteosarcomas JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2459 OP 2466 DO 10.21873/anticanres.13365 VO 39 IS 5 A1 KJETIL BERNER A1 ØYVIND S. BRULAND YR 2019 UL http://ar.iiarjournals.org/content/39/5/2459.abstract AB Background/Aim: This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. Patients and Methods: A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. Results: The univariate analysis results identified no significant differences in survival between patients with OS in proximal long bones (101 cases) as a group in comparison to patients with OS in the distal part of these bones (120 cases). However, proximal femur and primary metastasis were both independent adverse prognostic factors for sarcoma-specific survival in multivariate analyses, while elevated LDH and secondary OS were inferior prognostic factors for event-free survival. Adequate surgery and chemotherapy had a positive impact on survival. Conclusion: OS of the proximal femur had an unfavorable outcome in comparison to OS in other anatomical locations in extremity long bones.