PT - JOURNAL ARTICLE AU - KJETIL BERNER AU - ØYVIND S. BRULAND TI - Prognostic Impact of Proximal <em>Versus</em> Distal Localization in Extremity Long Bone Osteosarcomas AID - 10.21873/anticanres.13365 DP - 2019 May 01 TA - Anticancer Research PG - 2459--2466 VI - 39 IP - 5 4099 - http://ar.iiarjournals.org/content/39/5/2459.short 4100 - http://ar.iiarjournals.org/content/39/5/2459.full SO - Anticancer Res2019 May 01; 39 AB - Background/Aim: This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. Patients and Methods: A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. Results: The univariate analysis results identified no significant differences in survival between patients with OS in proximal long bones (101 cases) as a group in comparison to patients with OS in the distal part of these bones (120 cases). However, proximal femur and primary metastasis were both independent adverse prognostic factors for sarcoma-specific survival in multivariate analyses, while elevated LDH and secondary OS were inferior prognostic factors for event-free survival. Adequate surgery and chemotherapy had a positive impact on survival. Conclusion: OS of the proximal femur had an unfavorable outcome in comparison to OS in other anatomical locations in extremity long bones.