RT Journal Article SR Electronic T1 Cost-effectiveness of Multiparametric MRI in 800 Men Submitted to Repeat Prostate Biopsy: Results of a Public Health Model JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2395 OP 2398 VO 38 IS 4 A1 PEPE, PIETRO A1 PEPE, GABRIELE A1 PEPE, LUDOVICA A1 GARUFI, ANTONIO A1 PRIOLO, GIAN DOMENICO A1 PENNISI, MICHELE YR 2018 UL http://ar.iiarjournals.org/content/38/4/2395.abstract AB Background/Aim: To evaluate the cost-effectiveness of multiparametric magnetic imaging resonance (mpMRI) in men submitted to repeat saturation prostate biopsy (SPBx). Materials and Methods: From January 2011 to June 2017, 800 men underwent repeat SPBx; the cost-effectiveness of mpMRI if used as a ‘triage test’ to avoid unnecessary repeat prostate biopsy was retrospectively calculated using the Italian Public National Health System Day Service. Results: SPBx vs. MRI fusion targeted biopsy diagnosed 215 (89.5%) vs. 184 (76.6%) out of 240, respectively. The overall cost of the 800 prostate biopsies was 138,221 €; the use of mpMRI as triage test would have spared 364/800 procedures, equivalent to 60,905 € (44% of the entire cost), whilst missing 15/205 (7.3%) cases of clinically significant cancer. Conclusion: mpMRI used as a triage test could reduce the need for prostate biopsies by about 45%, thereby improving cost-effectiveness, however, patients should be informed of the false-negative rate associated with mpMRI.