PT - JOURNAL ARTICLE AU - ASTA JUZENIENE AU - JENNI BERNOULLI AU - MARI SUOMINEN AU - JUSSI HALLEEN AU - ROY HARTVIG LARSEN TI - Antitumor Activity of Novel Bone-seeking, α-emitting <sup>224</sup>Ra-solution in a Breast Cancer Skeletal Metastases Model DP - 2018 Apr 01 TA - Anticancer Research PG - 1947--1955 VI - 38 IP - 4 4099 - http://ar.iiarjournals.org/content/38/4/1947.short 4100 - http://ar.iiarjournals.org/content/38/4/1947.full SO - Anticancer Res2018 Apr 01; 38 AB - Background/Aim: Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells injected intracardially into nude mice. Materials and Methods: Vehicle, ethylenediamine tetra (methylene phosphonic acid) (EDTMP) and 224Ra-solution (45, 91 or 179 kBq/kg) with EDTMP were intravenously administered to mice two days after cell injection. The bone-seeking EDTMP was added to the 224Ra-solution to improve bone targeting of 212Pb, which is a progeny of 224Ra. Results: Radium-224 solution treatment decreased in a dose-dependent manner the areas of osteolytic lesions in the hind limbs and the number of tumor foci in the whole skeleton, and extended survival. Paraplegia was not observed in 179 kBq/kg 224Ra-solution group. Conclusion: Radium-224-solution containing chelated 212Pb is a promising candidate for the treatment of breast cancer patients with bone metastases.