PT - JOURNAL ARTICLE AU - LIESA DZIGGEL AU - NIKLAS GEBAUER AU - TOBIAS BARTSCHT AU - STEVEN E. SCHILD AU - DIRK RADES TI - Performance Status and Number of Metastatic Extra-cerebral Sites Predict Survival After Radiotherapy of Brain Metastases from Thyroid Cancer DP - 2018 Apr 01 TA - Anticancer Research PG - 2391--2394 VI - 38 IP - 4 4099 - http://ar.iiarjournals.org/content/38/4/2391.short 4100 - http://ar.iiarjournals.org/content/38/4/2391.full SO - Anticancer Res2018 Apr 01; 38 AB - Background/Aim: Patients with brain metastases from thyroid cancer are extremely rare. This study evaluated clinical factors for survival following whole-brain radiotherapy (WBRT) alone. Patients and Methods: In six patients, the following factors were analyzed for survival: Regimen of WBRT (5×4 Gy vs. 10×3 Gy), gender, age (≤55 vs. ≥56 years), Karnofsky performance score (KPS) (60% vs. 70-80%), number of brain lesions (2-3 vs. ≥4) and number of extra-cranial metastatic sites (one vs. more than one). Results: KPS 70-80% (p=0.036) and involvement of only one extra-cranial site (p=0.018) were associated with better survival on univariate analysis. On Cox regression analysis, KPS (p=0.14) and number of extra-cranial sites (p=0.14) showed trends for association with survival. In patients with KPS 70-80% and only one extra-cranial site, 6-month survival was 100%, no patient with KPS 60% and more than one extra-cranial site survived to 6 months. Conclusion: KPS and number of involved extra-cranial metastatic sites were associated with survival and may be helpful for individualizing therapy in patients with brain metastases from thyroid cancer.