TY - JOUR T1 - Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2339 LP - 2342 VL - 38 IS - 4 AU - NICHOLAS S. MASTRONIKOLIS AU - EVANGELOS TSIAMBAS AU - PANAGIOTIS P. FOTIADES AU - EVANGELIA BALIOU AU - ANDREAS KARAMERIS AU - DIMITRIOS PESCHOS AU - STYLIANOS N. MASTRONIKOLIS AU - ASIMAKIS D. ASIMAKOPOULOS AU - XENOFON GIANNAKOPOULOS AU - VASILEIOS RAGOS Y1 - 2018/04/01 UR - http://ar.iiarjournals.org/content/38/4/2339.abstract N2 - Background: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC. Materials and Methods: Using tissue microarray technology, 30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic in situ hybridization assay was performed based on Chr7 centromeric probedetection. Results: Chr 7 numerical analysis detected polysomy (trisomy/ tetrasomy) in 4/30 (13.3%) of the examined tissue OSCC cores. Statistical significance was assessed correlating Chr7 numerical aberrations with stage (p=0.015), especially detected in cases not related to human papillomavirus (HPV) (p=0.01). Conclusion: Although Chr7 polysomy is a relatively rare gross genetic event in OSSC, it affects their biological behavior leading toa progressively aggressive phenotype (advanced stage). Furthermore, Chr7 polysomy is observed more frequently in non-viral (HPV) cases. ER -