@article {MASTRONIKOLIS2339, author = {NICHOLAS S. MASTRONIKOLIS and EVANGELOS TSIAMBAS and PANAGIOTIS P. FOTIADES and EVANGELIA BALIOU and ANDREAS KARAMERIS and DIMITRIOS PESCHOS and STYLIANOS N. MASTRONIKOLIS and ASIMAKIS D. ASIMAKOPOULOS and XENOFON GIANNAKOPOULOS and VASILEIOS RAGOS}, title = {Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma}, volume = {38}, number = {4}, pages = {2339--2342}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC. Materials and Methods: Using tissue microarray technology, 30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic in situ hybridization assay was performed based on Chr7 centromeric probedetection. Results: Chr 7 numerical analysis detected polysomy (trisomy/ tetrasomy) in 4/30 (13.3\%) of the examined tissue OSCC cores. Statistical significance was assessed correlating Chr7 numerical aberrations with stage (p=0.015), especially detected in cases not related to human papillomavirus (HPV) (p=0.01). Conclusion: Although Chr7 polysomy is a relatively rare gross genetic event in OSSC, it affects their biological behavior leading toa progressively aggressive phenotype (advanced stage). Furthermore, Chr7 polysomy is observed more frequently in non-viral (HPV) cases.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/4/2339}, eprint = {https://ar.iiarjournals.org/content/38/4/2339.full.pdf}, journal = {Anticancer Research} }