RT Journal Article SR Electronic T1 The Role of MTHFR Genotype in Colorectal Cancer Susceptibility in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2001 OP 2006 VO 38 IS 4 A1 KUEI-MAN LIN A1 MEI-DUE YANG A1 CHIA-WEN TSAI A1 WEN-SHIN CHANG A1 CHIEH-LUN HSIAO A1 LONG-BIN JENG A1 TE-CHENG YUEH A1 MENG-CHIH LEE A1 DA-TIAN BAU YR 2018 UL http://ar.iiarjournals.org/content/38/4/2001.abstract AB Aim: To evaluate the contribution of methylenetetrahydrofolate reductase (MTHFR) genotype to the risk of colorectal cancer (CRC) in Taiwan. Materials and Methods: In this hospital-based case–control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals. Results: The percentages of CC, CT and TT genotypes for MTHFR rs1801133 were 64.1%, 29.8% and 6.1% in the CRC group and 51.1%, 37.0% and 11.9% in the control group, respectively (p for trend=0.0006). Analysis of the allelic frequency distribution showed that the variant T allele of MTHFR rs1801133 conferred a lower CRC susceptibility than did the wild-type C allele (odds ratio(OR)=0.66, 95% confidence interval(CI)=0.52-0.84, p=4.32×10−5). For the gene–lifestyle interaction, there were obvious protective effects of MTHFR rs1801133 T allele on the risk of CRC among non-smokers, ever smokers and non-alcohol drinkers, but not drinkers. Conclusion: MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings.