TY - JOUR T1 - Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 1685 LP - 1693 VL - 38 IS - 3 AU - MIKITO INOKUCHI AU - MASATOSHI NAKAGAWA AU - NASRI BAOGOK AU - YOKO TAKAGI AU - TOSHIRO TANIOKA AU - KENTARO GOKITA AU - KEISUKE OKUNO AU - KAZUYUKI KOJIMA Y1 - 2018/03/01 UR - http://ar.iiarjournals.org/content/38/3/1685.abstract N2 - Background/Aim: Erythropoietin-producing hepatocellular carcinoma receptor A (EphA) is associated with angiogenesis and invasive tumor progression. In this study, we evaluated the EphA1-4 expression levels in advanced gastric cancer. Patients and Methods: Tumor tissues obtained from 114 patients with advanced gastric adenocarcinoma who underwent gastrectomy were analyzed. In addition, the impact of EPHA 1-4 mRNA expression on survival was analyzed using the Kaplan-Meier plotter database on the website. Results: High EphA 1, 2, and 4 expression levels were significantly related to recurrence (p<0.01, p=0.04, and p<0.01). Both high EphA 1 and 4 expression levels were independent predictors of relapse-free interval (hazard ratio [HR]=2.0, p=0.03; HR=2.4, p=0.03) and disease-specific survival (HR=2.0, 95% p=0.03; HR=2.5, p=0.02) on multivariate analysis. In the Kaplan-Meier plotter database, high EPHA2 mRNA expression was significantly associated with poor survival in patients with gastric cancer (p=0.0098), and high expression levels of EPHA1 and 4 tended to be associated with poor survival (p=0.050, p=0.052). Conclusion: EphA 1, 2, and 4 may play key roles in recurrence and survival in patients with advanced gastric cancer. ER -