PT  - JOURNAL ARTICLE
AU  - IZUMI TACHIBANA
AU  - YASUMASA NISHIMURA
AU  - KOHEI HANAOKA
AU  - MASAHIRO INADA
AU  - KOHEI FUKUDA
AU  - HITOSHI TATEBE
AU  - KAZUKI ISHIKAWA
AU  - KIYOSHI NAKAMATSU
AU  - SHUICHI KANAMORI
AU  - MAKOTO HOSONO
TI  - Tumor Hypoxia Detected by <sup>18</sup>F-fluoromisonidazole Positron Emission Tomography (FMISO PET) as a Prognostic Indicator of Radiotherapy (RT)
DP  - 2018 Mar 01
TA  - Anticancer Research
PG  - 1775--1781
VI  - 38
IP  - 3
4099  - http://ar.iiarjournals.org/content/38/3/1775.short
4100  - http://ar.iiarjournals.org/content/38/3/1775.full
SO  - Anticancer Res2018 Mar 01; 38
AB  - Background/Aim: 18F-misonidazole positron emission tomography (FMISO PET)/computed tomography (CT) obtained before and during radiotherapy (RT) was analyzed as to whether it could predict clinical outcome. Patients and Methods: Twenty-two patients were included. FMISO PET/ CT was performed twice before RT and at a dose of approximately 20 Gy/10 fractions. FMISO maximum standardized uptake values (SUVmax), the tumor-to-muscle ratios (T/M), and hypoxic volume (HV) in gross target volumes were measured. Results: Of the 22 tumors, 18 had hypoxic areas (SUVmax ≥1.60) before RT. SUVmax, T/M, and HV on the first PET/CT were significantly correlated with initial tumor response, although the values during RT were not related to the response. The overall survival and loco-regional control rates of patients below cut-off values were significantly better than those above the cut-off values. Conclusion: Tumor hypoxia detected by FMISO PET/CT before RT may predict clinical outcome.