TY - JOUR T1 - Squamous Cell Carcinoma Antigen-encoding Genes <em>SERPINB3/B4</em> as Potentially Useful Markers for the Stratification of HNSCC Tumours JF - Anticancer Research JO - Anticancer Res SP - 1343 LP - 1352 VL - 38 IS - 3 AU - ZUZANA SAIDAK AU - MONY CHENDA MORISSE AU - DENIS CHATELAIN AU - CHLOÉ SAUZAY AU - ALINE HOUESSINON AU - NELLY GUILAIN AU - MARION SOYEZ AU - BRUNO CHAUFFERT AU - STÉPHANIE DAKPÉ AU - ANTOINE GALMICHE Y1 - 2018/03/01 UR - http://ar.iiarjournals.org/content/38/3/1343.abstract N2 - Background/Aim: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. Materials and Methods: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). Results: HNSCC tumours express high levels of SERPINB3/B4 mRNA. SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread. Interestingly, we observed an association between SERPINB3/B4 and the presence of tumour immune infiltrate as well as the expression of the immune checkpoint regulators PD-L1/PD-L2 that depended on HPV status. Conclusion: Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context. ER -