@article {SAIDAK1343, author = {ZUZANA SAIDAK and MONY CHENDA MORISSE and DENIS CHATELAIN and CHLO{\'E} SAUZAY and ALINE HOUESSINON and NELLY GUILAIN and MARION SOYEZ and BRUNO CHAUFFERT and ST{\'E}PHANIE DAKP{\'E} and ANTOINE GALMICHE}, title = {Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours}, volume = {38}, number = {3}, pages = {1343--1352}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. Materials and Methods: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). Results: HNSCC tumours express high levels of SERPINB3/B4 mRNA. SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread. Interestingly, we observed an association between SERPINB3/B4 and the presence of tumour immune infiltrate as well as the expression of the immune checkpoint regulators PD-L1/PD-L2 that depended on HPV status. Conclusion: Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/3/1343}, eprint = {https://ar.iiarjournals.org/content/38/3/1343.full.pdf}, journal = {Anticancer Research} }