PT - JOURNAL ARTICLE AU - GIAMBATTISTA SIEPE AU - MILLY BUWENGE AU - NAM P. NGUYEN AU - GABRIELLA MACCHIA AU - FRANCESCO DEODATO AU - SAVINO CILLA AU - GIAN C. MATTIUCCI AU - ILARIA CAPOCACCIA AU - SILVIA CAMMELLI AU - ALESSANDRA GUIDO AU - ALESSANDRA ARCELLI AU - MARIA NTRETA AU - SARA GUERRI AU - ALESSIO G. MORGANTI TI - Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review DP - 2018 Mar 01 TA - Anticancer Research PG - 1221--1230 VI - 38 IP - 3 4099 - http://ar.iiarjournals.org/content/38/3/1221.short 4100 - http://ar.iiarjournals.org/content/38/3/1221.full SO - Anticancer Res2018 Mar 01; 38 AB - Background/Aim: A systematic review on toxicity, local control (LC), overall survival (OS), and biochemical relapse-free survival (bRFS) after postoperative hypofractionated radiotherapy (HFRT) on prostate cancer (PCa) was performed. Materials and Methods: Based on the PRISMA methodology, studies reporting clinical results after adjuvant or salvage HFRT were included. Results: A total of 1,208 patients from 17 eligible studies were included. Median follow-up was 30 months. No case of severe acute gastrointestinal (GI) toxicity was recorded. Grade ≥3 acute genitourinary (GU) toxicity ranged between 0% and 3%. Different rates of grade ≥2 late GI (range=0-8.7%) and GU (range=0-66%) toxicity were recorded. Encouraging results on LC, OS, and bRFS were reported. Conclusion: Acute toxicity does not seem to be increased in patients receiving postoperative HFRT, but the results of late-GU toxicity are conflicting. Further prospective studies are needed before including postoperative HFRT in clinical practice.