%0 Journal Article %A GIAMBATTISTA SIEPE %A MILLY BUWENGE %A NAM P. NGUYEN %A GABRIELLA MACCHIA %A FRANCESCO DEODATO %A SAVINO CILLA %A GIAN C. MATTIUCCI %A ILARIA CAPOCACCIA %A SILVIA CAMMELLI %A ALESSANDRA GUIDO %A ALESSANDRA ARCELLI %A MARIA NTRETA %A SARA GUERRI %A ALESSIO G. MORGANTI %T Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review %D 2018 %J Anticancer Research %P 1221-1230 %V 38 %N 3 %X Background/Aim: A systematic review on toxicity, local control (LC), overall survival (OS), and biochemical relapse-free survival (bRFS) after postoperative hypofractionated radiotherapy (HFRT) on prostate cancer (PCa) was performed. Materials and Methods: Based on the PRISMA methodology, studies reporting clinical results after adjuvant or salvage HFRT were included. Results: A total of 1,208 patients from 17 eligible studies were included. Median follow-up was 30 months. No case of severe acute gastrointestinal (GI) toxicity was recorded. Grade ≥3 acute genitourinary (GU) toxicity ranged between 0% and 3%. Different rates of grade ≥2 late GI (range=0-8.7%) and GU (range=0-66%) toxicity were recorded. Encouraging results on LC, OS, and bRFS were reported. Conclusion: Acute toxicity does not seem to be increased in patients receiving postoperative HFRT, but the results of late-GU toxicity are conflicting. Further prospective studies are needed before including postoperative HFRT in clinical practice. %U https://ar.iiarjournals.org/content/anticanres/38/3/1221.full.pdf