@article {SIEPE1221, author = {GIAMBATTISTA SIEPE and MILLY BUWENGE and NAM P. NGUYEN and GABRIELLA MACCHIA and FRANCESCO DEODATO and SAVINO CILLA and GIAN C. MATTIUCCI and ILARIA CAPOCACCIA and SILVIA CAMMELLI and ALESSANDRA GUIDO and ALESSANDRA ARCELLI and MARIA NTRETA and SARA GUERRI and ALESSIO G. MORGANTI}, title = {Postoperative Hypofractionated Radiation Therapy in Prostate Carcinoma: A Systematic Review}, volume = {38}, number = {3}, pages = {1221--1230}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: A systematic review on toxicity, local control (LC), overall survival (OS), and biochemical relapse-free survival (bRFS) after postoperative hypofractionated radiotherapy (HFRT) on prostate cancer (PCa) was performed. Materials and Methods: Based on the PRISMA methodology, studies reporting clinical results after adjuvant or salvage HFRT were included. Results: A total of 1,208 patients from 17 eligible studies were included. Median follow-up was 30 months. No case of severe acute gastrointestinal (GI) toxicity was recorded. Grade >=3 acute genitourinary (GU) toxicity ranged between 0\% and 3\%. Different rates of grade >=2 late GI (range=0-8.7\%) and GU (range=0-66\%) toxicity were recorded. Encouraging results on LC, OS, and bRFS were reported. Conclusion: Acute toxicity does not seem to be increased in patients receiving postoperative HFRT, but the results of late-GU toxicity are conflicting. Further prospective studies are needed before including postoperative HFRT in clinical practice.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/3/1221}, eprint = {https://ar.iiarjournals.org/content/38/3/1221.full.pdf}, journal = {Anticancer Research} }