<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MOUTINHO, MAGDA S.S.</style></author><author><style face="normal" font="default" size="100%">ARAGÃO, SOFIA</style></author><author><style face="normal" font="default" size="100%">CARMO, DIOGO</style></author><author><style face="normal" font="default" size="100%">CASACA, FÁTIMA</style></author><author><style face="normal" font="default" size="100%">SILVA, SANDRA</style></author><author><style face="normal" font="default" size="100%">RIBEIRO, JOANA</style></author><author><style face="normal" font="default" size="100%">SOUSA, HUGO</style></author><author><style face="normal" font="default" size="100%">PIRES, ISABEL</style></author><author><style face="normal" font="default" size="100%">QUEIROGA, FELISBINA</style></author><author><style face="normal" font="default" size="100%">COLAÇO, BRUNO</style></author><author><style face="normal" font="default" size="100%">MEDEIROS, RUI</style></author><author><style face="normal" font="default" size="100%">OLIVEIRA, PAULA A.</style></author><author><style face="normal" font="default" size="100%">LOPES, CARLOS</style></author><author><style face="normal" font="default" size="100%">BASTOS, MARGARIDA M.S.M.</style></author><author><style face="normal" font="default" size="100%">DA COSTA, RUI M. GIL</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1461-1466</style></pages><volume><style face="normal" font="default" size="100%">38</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Materials and Methods: Six-week-old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16−/− no treatment, n=12; HPV16+/− no treatment, n=13; HPV16+/− rutin, n=12; HPV16+/− curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Results: Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. Conclusion: COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies.</style></abstract></record></records></xml>