TY - JOUR T1 - A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas JF - Anticancer Research JO - Anticancer Res SP - 1665 LP - 1670 VL - 38 IS - 3 AU - HIROAKI SUEFUJI AU - MASASHI KOTO AU - YUSUKE DEMIZU AU - JUN-ICHI SAITOH AU - YOSHIYUKI SHIOYAMA AU - HIROSHI TSUJI AU - TOMOAKI OKIMOTO AU - TATSUYA OHNO AU - KENJI NEMOTO AU - TAKASHI NAKANO AU - TADASHI KAMADA Y1 - 2018/03/01 UR - http://ar.iiarjournals.org/content/38/3/1665.abstract N2 - The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings. ER -