RT Journal Article
SR Electronic
T1 mTORC1 and mTORC2 Expression Levels in Oral Squamous Cell Carcinoma: An Immunohistochemical and Clinicopathological Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1623
OP 1628
VO 38
IS 3
A1 GORO KAWASAKI
A1 TOMOFUMI NARUSE
A1 KOHEI FURUKAWA
A1 MASAHIRO UMEDA
YR 2018
UL http://ar.iiarjournals.org/content/38/3/1623.abstract
AB Background/Aim: Mammalian target of rapamycin (mTOR) plays a critical role in the regulation of tumor cell motility, invasion and cancer cell metastasis. mTOR consists of two separate multi-protein complexes, mTOR complex (mTORC) 1 and mTORC2. Materials and Methods: We investigated the expression levels of mTORC1 and mTORC2 immunohistochemically in oral squamous cell carcinoma (OSCC). Results: mTORC1 and mTORC2 were more highly expressed in tumors than in normal oral mucosa. mTORC1 expression was correlated with T classification, N classification, and survival rate (p<0.05), whereas mTORC2 expression was only correlated with T classification (p<0.05). Histologically, the expression levels of mTORC1 and mTORC2 correlated with cancer cell invasion and the expression of proliferating cell nuclear antigen (p<0.05), respectively. Expression levels of vascular endothelial growth factors and hypoxia-inducible factor 1 in the mTORC1 (−)/ mTORC2 (+) group were significantly lower than those in other groups. Conclusion: These findings suggested that mTORC1 and mTORC2 could be promising anti-tumor targets in OSCC, and mTORC1 (−)/mTORC2 (+) may have a correlation with the malignant potential of OSCC.