@article {KAWASAKI1623, author = {GORO KAWASAKI and TOMOFUMI NARUSE and KOHEI FURUKAWA and MASAHIRO UMEDA}, title = {mTORC1 and mTORC2 Expression Levels in Oral Squamous Cell Carcinoma: An Immunohistochemical and Clinicopathological Study}, volume = {38}, number = {3}, pages = {1623--1628}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Mammalian target of rapamycin (mTOR) plays a critical role in the regulation of tumor cell motility, invasion and cancer cell metastasis. mTOR consists of two separate multi-protein complexes, mTOR complex (mTORC) 1 and mTORC2. Materials and Methods: We investigated the expression levels of mTORC1 and mTORC2 immunohistochemically in oral squamous cell carcinoma (OSCC). Results: mTORC1 and mTORC2 were more highly expressed in tumors than in normal oral mucosa. mTORC1 expression was correlated with T classification, N classification, and survival rate (p\<0.05), whereas mTORC2 expression was only correlated with T classification (p\<0.05). Histologically, the expression levels of mTORC1 and mTORC2 correlated with cancer cell invasion and the expression of proliferating cell nuclear antigen (p\<0.05), respectively. Expression levels of vascular endothelial growth factors and hypoxia-inducible factor 1 in the mTORC1 (-)/ mTORC2 (+) group were significantly lower than those in other groups. Conclusion: These findings suggested that mTORC1 and mTORC2 could be promising anti-tumor targets in OSCC, and mTORC1 (-)/mTORC2 (+) may have a correlation with the malignant potential of OSCC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/3/1623}, eprint = {https://ar.iiarjournals.org/content/38/3/1623.full.pdf}, journal = {Anticancer Research} }