TY - JOUR T1 - A Feasibility Study of Capecitabine and Oxaliplatin for Patients with Stage II/III Colon Cancer –ACTOR Study– JF - Anticancer Research JO - Anticancer Res SP - 1741 LP - 1747 VL - 38 IS - 3 AU - MITSUKUNI SUENAGA AU - TAKASHI AKIYOSHI AU - EIJI SHINOZAKI AU - YOSHIYA FUJIMOTO AU - SATOSHI MATSUSAKA AU - TSUYOSHI KONISHI AU - SATOSHI NAGAYAMA AU - YOSUKE FUKUNAGA AU - KAZUYOSHI KAWAKAMI AU - TAKASHI YOKOKAWA AU - TAKAHITO SUGISAKI AU - MASASHI UENO AU - TOSHIHARU YAMAGUCHI Y1 - 2018/03/01 UR - http://ar.iiarjournals.org/content/38/3/1741.abstract N2 - Background/Aim: Past studies have suggested that adjuvant capecitabine and oxaliplatin (CAPOX) provides decreased tumor relapse and longer survival in patients with curatively resected colon cancer. We report the first evidence of the feasibility of adjuvant CAPOX in Japanese patients with early colon cancer. Patients and Methods: Eligible patients had histologically-confirmed stage II/III colon cancer and received curative resection. The primary endpoint was completion rate of treatment after 8 cycles of adjuvant CAPOX. Results: Thirty-six patients were enrolled in this study. The completion rate of CAPOX and oxaliplatin were 77.8% and 61.1%, respectively. The incidence of grade ≥3 adverse events was neutropenia (n=6), thrombocytopenia (n=3), nausea (n=5), hand-foot syndrome (n=1) and peripheral sensory neuropathy (n=1). Three-year disease-free survival for stage II patients and stage III patients were 100% and 79.3%, respectively. Conclusion: Adjuvant CAPOX can be safely administered to Japanese patients with stage II/III colon cancer. ER -