TY - JOUR T1 - Analytical Methods for Quantification of Vitamin D and Implications for Research and Clinical Practice JF - Anticancer Research JO - Anticancer Res SP - 1137 LP - 1144 VL - 38 IS - 2 AU - CAROLINE S. STOKES AU - FRANK LAMMERT AU - DIETRICH A. VOLMER Y1 - 2018/02/01 UR - http://ar.iiarjournals.org/content/38/2/1137.abstract N2 - A plethora of contradictory research surrounds vitamin D and its influence on health and disease. This may, in part, result from analytical difficulties with regard to measuring vitamin D metabolites in serum. Indeed, variation exists between analytical techniques and assays used for the determination of serum 25-hydroxyvitamin D. Research studies into the effects of vitamin D on clinical endpoints rely heavily on the accurate assessment of vitamin D status. This has important implications, as findings from vitamin D-related studies to date may potentially have been hampered by the quantification techniques used. Likewise, healthcare professionals are increasingly incorporating vitamin D testing and supplementation regimens into their practice, and measurement errors may be also confounding the clinical decisions. Importantly, the Vitamin D Standardisation Programme is an initiative that aims to standardise the measurement of vitamin D metabolites. Such a programme is anticipated to eliminate the inaccuracies surrounding vitamin D quantification. ER -