RT Journal Article
SR Electronic
T1 Centrosomal Abnormalities in Pancreatic Cancer: Molecular Mechanisms and Clinical Implications
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1241
OP 1245
VO 38
IS 3
A1 DANIEL ANSARI
A1 CAROLINA DEL PINO BELLIDO
A1 MONIKA BAUDEN
A1 ROLAND ANDERSSON
YR 2018
UL http://ar.iiarjournals.org/content/38/3/1241.abstract
AB The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.