TY - JOUR T1 - Centrosomal Abnormalities in Pancreatic Cancer: Molecular Mechanisms and Clinical Implications JF - Anticancer Research JO - Anticancer Res SP - 1241 LP - 1245 VL - 38 IS - 3 AU - DANIEL ANSARI AU - CAROLINA DEL PINO BELLIDO AU - MONIKA BAUDEN AU - ROLAND ANDERSSON Y1 - 2018/03/01 UR - http://ar.iiarjournals.org/content/38/3/1241.abstract N2 - The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment. ER -