@article {IMAI1053, author = {KATSUNORI IMAI and YO-ICHI YAMASHITA and TOSHIHIKO YUSA and YOSUKE NAKAO and RUMI ITOYAMA and SHIGEKI NAKAGAWA and HIROHISA OKABE and AKIRA CHIKAMOTO and TAKATOSHI ISHIKO and HIDEO BABA}, title = {Microvascular Invasion in Small-sized Hepatocellular Carcinoma: Significance for Outcomes Following Hepatectomy and Radiofrequency Ablation}, volume = {38}, number = {2}, pages = {1053--1060}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. Patients and Methods: We studied 149 patients with solitary small-sized HCC (<=3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent factors related to the presence of MVI. The predictive model was applied to 159 patients who underwent RFA, and their outcomes were examined. Results: A multivariate analysis revealed that α-fetoprotein >=15 ng/ml (relative risk (RR) 3.05, p=0.02), des-γ-carboxy prothrombin >=100 mAU/ml (RR 4.19, p=0.003), and tumor size >=2 cm (RR 3.37, p=0.03) were independent risk factors of MVI. Among the patients who underwent RFA, the survival in patients with risk factors 2-3 was significantly worse, and local recurrence was more frequently obserbed than those with 0-1. Conclusion: When an HCC tumor is expected to display MVI, RFA may not be suitable in terms of poorer survival and local disease-control rates.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/2/1053}, eprint = {https://ar.iiarjournals.org/content/38/2/1053.full.pdf}, journal = {Anticancer Research} }