RT Journal Article SR Electronic T1 The Mesenchymal–Epithelial and Epithelial–Mesenchymal Cellular Plasticity of Liver Metastases with Digestive Origin JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 811 OP 816 VO 38 IS 2 A1 AMALIA RALUCA CEAUSU A1 ALEXANDRU CIOLOFAN A1 ANCA MARIA CIMPEAN A1 ADINA MAGHETI A1 OVIDIU MEDERLE A1 MARIUS RAICA YR 2018 UL http://ar.iiarjournals.org/content/38/2/811.abstract AB Background: Few data are available regarding the epithelial to mesenchymal transition (EMT) /mesenchymal to epitheilal transition (MET) in the liver metastasis of digestive cancers. The aim of this study was to establish EMT/MET metastatic tumor cell plasticity according to the histological growth pattern of liver metastases. Materials and Methods: Biopsies from 25 patients with liver metastasis (desmoplastic, replacement and pushing type) were evaluated. Double immunostaining of E-cadherin/vimentin, keratin 8,18/vimentin and E-cadherin/ keratin 8,18 were performed. Results: The following cell types were noted: epithelial, mesenchymal, non-differentiated and differentiated hybrid mesenchymal/ epithelial and non-hybrid phenotype. All cases had mesenchymal/ epithelial phenotype cells. A significant correlation was found between the non-differentiated hybrid mesenchymal/ epithelial phenotype metastatic cells and histological growth pattern for gastric and colorectal cancer. Conclusion: A MET-targeting strategy, in conjunction with conventional chemotherapy, may be useful for the treatment of liver metastases.