PT  - JOURNAL ARTICLE
AU  - AMALIA RALUCA CEAUSU
AU  - ALEXANDRU CIOLOFAN
AU  - ANCA MARIA CIMPEAN
AU  - ADINA MAGHETI
AU  - OVIDIU MEDERLE
AU  - MARIUS RAICA
TI  - The Mesenchymal–Epithelial and Epithelial–Mesenchymal Cellular Plasticity of Liver Metastases with Digestive Origin
DP  - 2018 Feb 01
TA  - Anticancer Research
PG  - 811--816
VI  - 38
IP  - 2
4099  - http://ar.iiarjournals.org/content/38/2/811.short
4100  - http://ar.iiarjournals.org/content/38/2/811.full
SO  - Anticancer Res2018 Feb 01; 38
AB  - Background: Few data are available regarding the epithelial to mesenchymal transition (EMT) /mesenchymal to epitheilal transition (MET) in the liver metastasis of digestive cancers. The aim of this study was to establish EMT/MET metastatic tumor cell plasticity according to the histological growth pattern of liver metastases. Materials and Methods: Biopsies from 25 patients with liver metastasis (desmoplastic, replacement and pushing type) were evaluated. Double immunostaining of E-cadherin/vimentin, keratin 8,18/vimentin and E-cadherin/ keratin 8,18 were performed. Results: The following cell types were noted: epithelial, mesenchymal, non-differentiated and differentiated hybrid mesenchymal/ epithelial and non-hybrid phenotype. All cases had mesenchymal/ epithelial phenotype cells. A significant correlation was found between the non-differentiated hybrid mesenchymal/ epithelial phenotype metastatic cells and histological growth pattern for gastric and colorectal cancer. Conclusion: A MET-targeting strategy, in conjunction with conventional chemotherapy, may be useful for the treatment of liver metastases.