TY - JOUR T1 - Association of Preoperative Nutritional Status with Prognosis in Patients with Esophageal Cancer Undergoing Salvage Esophagectomy JF - Anticancer Research JO - Anticancer Res SP - 933 LP - 938 VL - 38 IS - 2 AU - MAKOTO SAKAI AU - MAKOTO SOHDA AU - TATSUYA MIYAZAKI AU - TOMONORI YOSHIDA AU - YUJI KUMAKURA AU - HIROAKI HONJO AU - KEIGO HARA AU - DAIGO OZAWA AU - SHIGEMASA SUZUKI AU - NARITAKA TANAKA AU - TAKEHIKO YOKOBORI AU - HIROYUKI KUWANO Y1 - 2018/02/01 UR - http://ar.iiarjournals.org/content/38/2/933.abstract N2 - Background: To investigate whether malnutrition is associated with poor prognosis of patients who undergo salvage esophagectomy. We examined the association between the preoperative prognostic nutritional index (PNI) and prognosis of patients who undergo salvage esophagectomy. Patients and Methods: We conducted a single-center retrospective study and reviewed hospital patient records for tumor characteristics and patient outcomes. Univariate and multivariate survival analyses were carried out using the Cox proportional hazards regression model. Results: Thirty-two patients with esophageal squamous cell carcinoma (ESCC) who underwent salvage esophagectomy between 1998 and 2015 at our Institute were included in this study. Univariate analysis revealed that clinical response (p=0.045), preoperative PNI (p<0.001), pT (p=0.024), pN (p=0.004), and residual tumors (p<0.001) were significant prognostic factor for overall survival. Multivariate analysis using age and these five variables found no independent prognostic factors. Multivariate analysis using three preoperative variables (age, clinical response, and preoperative PNI) revealed that PNI was an independent prognostic preoperative factor for overall survival (p=0.005). Conclusion: Preoperative nutritional status is associated with the prognosis of patients undergoing salvage esophagectomy. ER -