RT Journal Article SR Electronic T1 Combination of Osthole and Cisplatin Against Rhabdomyosarcoma TE671 Cells Yielded Additive Pharmacologic Interaction by Means of Isobolographic Analysis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 205 OP 210 VO 38 IS 1 A1 AGATA JARZĄB A1 JAROGNIEW ŁUSZCZKI A1 MAŁGORZATA GUZ A1 KRYSTYNA SKALICKA-WOŹNIAK A1 MARTA HAŁASA A1 JOLANTA SMOK-KALWAT A1 KRZYSZTOF POLBERG A1 ANDRZEJ STEPULAK YR 2018 UL http://ar.iiarjournals.org/content/38/1/205.abstract AB Background/Aim: Osthole is a simple coumarin that has been found to have anticancer, anti-inflammatory, antiviral, anticoagulant, anticonvulsant and antiallergic activities. The aim of this study was to analyze the combined anti-proliferative effect of cisplatin (CDDP) and osthole on a rhabdomyosarcoma cell line, and assess the pharmacology of drug-drug interaction between these drugs using isobolographic analysis. Materials and Methods: The anticancer actions of osthole in combination with CDDP were evaluated using the tetrazolium dye-based MTT cell proliferation assay. Results: Osthole and CDDP applied together augmented their anti-cancer activities and yielded an additive type of pharmacologic interaction by means of isobolographic analysis. Conclusion: Combined therapy using osthole and cisplatin could be suggested as a potential chemotherapy regimen against rhabdomyosarcoma.