PT  - JOURNAL ARTICLE
AU  - YOUNG WHA KOH
AU  - SEONG YONG PARK
AU  - SEUNG HYUP HYUN
AU  - SU JIN LEE
TI  - Associations Between PET Textural Features and GLUT1 Expression, and the Prognostic Significance of Textural Features in Lung Adenocarcinoma
DP  - 2018 Feb 01
TA  - Anticancer Research
PG  - 1067--1071
VI  - 38
IP  - 2
4099  - http://ar.iiarjournals.org/content/38/2/1067.short
4100  - http://ar.iiarjournals.org/content/38/2/1067.full
SO  - Anticancer Res2018 Feb 01; 38
AB  - Background/Aim: We evaluated the association between positron emission tomography (PET) textural features and glucose transporter 1 (GLUT1) expression level and further investigated the prognostic significance of textural features in lung adenocarcinoma. Patients and Methods: We evaluated 105 adenocarcinoma patients. We extracted texture-based PET parameters of primary tumors. Conventional PET parameters were also measured. The relationships between PET parameters and GLUT1 expression levels were evaluated. The association between PET parameters and overall survival (OS) was assessed using Cox's proportional hazard regression models. Results: In terms of PET textural features, tumors expressing high levels of GLUT1 exhibited significantly lower coarseness, contrast, complexity, and strength, but significantly higher busyness. On univariate analysis, the metabolic tumor volume, total lesion glycolysis, contrast, busyness, complexity, and strength were significant predictors of OS. Multivariate analysis showed that lower complexity (HR=2.017, 95%CI=1.032-3.942, p=0.040) was independently associated with poorer survival. Conclusion: PET textural features may aid risk stratification in lung adenocarcinoma patients.