RT Journal Article SR Electronic T1 Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1105 OP 1110 VO 38 IS 2 A1 YUE ZHAO A1 GUANG-WU XIONG A1 XIAO-WEI ZHANG A1 BO HANG YR 2018 UL http://ar.iiarjournals.org/content/38/2/1105.abstract AB Background/Aim: To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles. Materials and Methods: We searched electronic databases included Medline, WOK, Cochrane Library and CNKI, through January 24, 2015. Experts were consulted, and references from related articles were examined. The meta-analysis was conducted with RevMan5.3, according to the PRISMA guidelines. Mantel-Haenszel estimates were calculated and pooled under a random effect model, with data expressed as odds ratio (OR) and 95% confidence interval (CI). Results: We analyzed eight trials with a total of 337 participants who underwent uterine curettage and met the inclusion criteria. A significantly higher expression of Ki-67 was observed in complete than in partial hydatidiform moles (OR=3.28; 95%CI=1.80-5.96; p<0.0001). Conclusion: The Ki-67 expression was higher in complete than in partial hydatidiform moles. Therefore, Ki-67 may be of diagnostic value in distinguishing between partial and complete hydatidiform moles. However, the present study had only a limited number of samples, so investigation of a greater number of cases is needed to confirm this conclusion.