RT Journal Article
SR Electronic
T1 Low Expression of CD44 Is an Independent Factor of Poor Prognosis in Ovarian Mucinous Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 717
OP 722
VO 38
IS 2
A1 HIROKO MATUURA
A1 MORIKAZU MIYAMOTO
A1 MASASHI TAKANO
A1 HIROAKI SOYAMA
A1 TADASHI AOYAMA
A1 TOMOYUKI YOSHIKAWA
A1 KENTO KATO
A1 TAKAHIRO SAKAMOTO
A1 MIKA KUWAHARA
A1 KAZUKI TAKASAKI
A1 HIROKI ISHIBASHI
A1 HIDEKI IWAHASHI
A1 HITOSHI TSUDA
A1 KENICHI FURUYA
YR 2018
UL http://ar.iiarjournals.org/content/38/2/717.abstract
AB Aim: To determine whether CD44, which is associated with tumor growth and metastasis, is related to carcinogenesis and prognosis in ovarian mucinous carcinomas (MACs). Materials and Methods: Tissue blocks from 71 patients with benign mucinous ovarian tumors were used in the study: 35 were from patients with borderline mucinous ovarian tumors, and 60 from patients with MACs. Immunochemical analysis was performed to evaluate the expression of CD44 and examine its association with tumorigenesis and survival. Results: Compared to benign tumors, borderline tumors had high CD44 expression levels (p=0.047). Conversely, MACs had lower expression than borderline tumors (p=0.032). Progression-free and overall survival of patients with MAC with low CD44 expression were worse than those of patients with high expression (p=0.04 and p=0.02, respectively). Conclusion: Malignant transformation of mucinous tumors is associated with changes in CD44 expression, with low expression level being a prognostic factor in MAC.