%0 Journal Article %A SARKA SVOBODOVA %A RADEK KUCERA %A ONDREJ FIALA %A MARIE KARLIKOVA %A ANDREA NARSANSKA %A ILONA ZEDNÍKOVÁ %A VLADISLAV TRESKA %A DAVID SLOUKA %A MILENA ROUSAROVA %A ONDREJ TOPOLCAN %A JINDRICH FINEK %T CEA, CA 15-3, and TPS as Prognostic Factors in the Follow-up Monitoring of Patients After Radical Surgery for Breast Cancer %D 2018 %J Anticancer Research %P 465-469 %V 38 %N 1 %X Aim: The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery. Patients and Methods: Four hundred and seventy-two patients with breast cancer were evaluated. TPS, CEA, and CA 15-3 were measured in months 1, 3, and 6, after surgery. Disease recurrence was recorded between 7-12 months after surgery. Disease recurrence occurred in 60 patients, while 412 patients remained in recurrence-free status. Results: TPS levels of the recurrence group differed statistically significantly in the first and sixth month after surgery compared to recurrence-free group (p=0.0339, AUC=0.6056; p<0.0001, AUC=0.7196). CEA and CA 15-3 measurements did not achieve a statistically significant difference for any month examined. Conclusion: TPS level in the sixth month after surgery is the best candidate biomarker to predict disease recurrence. %U https://ar.iiarjournals.org/content/anticanres/38/1/465.full.pdf