PT  - JOURNAL ARTICLE
AU  - MICHAEL GLEI
AU  - SONJA FISCHER
AU  - JULIA LAMBERTY
AU  - DIANA LUDWIG
AU  - STEFAN LORKOWSKI
AU  - WIEBKE SCHLÖRMANN
TI  - Chemopreventive Potential of <em>In Vitro</em> Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells
DP  - 2018 Jan 01
TA  - Anticancer Research
PG  - 83--93
VI  - 38
IP  - 1
4099  - http://ar.iiarjournals.org/content/38/1/83.short
4100  - http://ar.iiarjournals.org/content/38/1/83.full
SO  - Anticancer Res2018 Jan 01; 38
AB  - Background/Aim: Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. Materials and Methods: Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180.4°C/21 min) on chemopreventive effects of in vitro fermented hazelnuts was analyzed in LT97 colon adenoma cells. Results: FS (2.5%) of raw and roasted hazelnuts reduced H2O2-induced DNA damage while 5% FS significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold). GPx1 mRNA levels were significantly decreased (0.6-fold) by FS (2.5%). The growth of LT97 cells was significantly reduced by hazelnut FS in a time- and dose-dependent manner. Hazelnut FS (5%) increased the numbers of early apoptotic cells (9.6% on average) and caspase-3 activities (6.4-fold on average). Conclusion: These results indicate a chemopreventive potential of in vitro fermented hazelnuts which is largely unaffected by the roasting process.