TY - JOUR T1 - Histone Deacetylase Inhibitors as a Novel Targeted Therapy Against Non-small Cell Lung Cancer: Where Are We Now and What Should We Expect? JF - Anticancer Research JO - Anticancer Res SP - 37 LP - 43 VL - 38 IS - 1 AU - CHRISTOS DAMASKOS AU - IOANNIS TOMOS AU - NIKOLAOS GARMPIS AU - ANNA KARAKATSANI AU - DIMITRIOS DIMITROULIS AU - ANNA GARMPI AU - ELEFTHERIOS SPARTALIS AU - CHRISTOS F. KAMPOLIS AU - ELENI TSAGKARI AU - ANGELIKI A. LOUKERI AU - GEORGIOS-ANTONIOS MARGONIS AU - MICHAEL SPARTALIS AU - NIKOLAOS ANDREATOS AU - DIMITRIOS SCHIZAS AU - STEFANIA KOKKINELI AU - EFSTATHIOS A. ANTONIOU AU - AFRODITI NONNI AU - GERASIMOS TSOUROUFLIS AU - KONSTANTINOS MARKATOS AU - KONSTANTINOS KONTZOGLOU AU - ALKIVIADIS KOSTAKIS AU - PERIKLIS TOMOS Y1 - 2018/01/01 UR - http://ar.iiarjournals.org/content/38/1/37.abstract N2 - Non-small cell lung cancer constitutes the most common type of lung cancer, accounting for 85-90% of lung cancer, and is a leading cause of cancer-related death. Despite the progress during the past years, poor prognosis remains a challenge and requires further research and development of novel antitumor treatment. Recently, the role of histone deacetylases in gene expression has emerged showing their regulation of the acetylation of histone proteins and other non-histone protein targets and their role in chromatin organization, while their inhibitors, the histone deacetylase inhibitors, have been proposed to have a potential therapeutic role in diverse malignancies, including non-small cell lung cancer. This review article focuses on the role of histone deacetylase inhibitors in the treatment of non-small cell lung cancer and the major molecular mechanisms underlying their antitumor activity recognized so far. ER -