PT - JOURNAL ARTICLE AU - TAKEFUMI KATSUKI AU - YOSHIFUMI NAKAYAMA AU - MASAKI AKIYAMA AU - YUSUKE SAWATSUBASHI AU - JUN NAGATA AU - NORITAKA MINAGAWA AU - TAKAYUKI TORIGOE AU - HIROTO IZUMI AU - KIMITOSHI KOHONO AU - KEIJI HIRATA TI - Prognostic Significance of Mitochondrial Transcription Factor A Expression in Patients with Right- or Left-sided Colorectal Cancer DP - 2018 Jan 01 TA - Anticancer Research PG - 569--575 VI - 38 IP - 1 4099 - http://ar.iiarjournals.org/content/38/1/569.short 4100 - http://ar.iiarjournals.org/content/38/1/569.full SO - Anticancer Res2018 Jan 01; 38 AB - Background/Aim: Mitochondrial transcription factor A (mtTFA) is necessary for both the transcription and maintenance of mitochondrial DNA (mtDNA). The present study investigated the clinical significance of mtTFA in patients with right- and left-sided colorectal cancer (CRC). Patients and Methods: Surgical specimens from 237 CRC patients were immunohistochemically stained with polyclonal anti-mtTFA antibody. The relationships among the mtTFA expression, clinicopathological factors and prognosis were evaluated. Results: Thirty-five (60.3%) of 58 right-sided CRC patients and 82 (45.8%) of 179 left-sided CRC patients showed high mtTFA expression. The mtTFA expression significantly correlated with lymph node metastasis, distant metastasis, the TNM stage and lymphatic invasion in left-sided CRC patients and did not correlate with any factors in right-sided CRC patients. Univariate and multivariate analyses revealed the mtTFA expression to be a significant prognostic factor in left-sided CRC patients but not in right-sided CRC patients. Conclusion: These results suggest that a high mtTFA expression is a useful marker for tumor progression and a poor prognosis in left-sided CRC patients.