TY - JOUR T1 - Safety and Efficacy of Low-dose Nanoparticle Albumin-bound Paclitaxel for HER2-negative Metastatic Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 379 LP - 383 VL - 38 IS - 1 AU - TSUTOMU TAKASHIMA AU - HIDEMI KAWAJIRI AU - TAKEO NISHIMORI AU - SEIKA TEI AU - SHIGEHIKO NISHIMURA AU - SHIGEHITO YAMAGATA AU - SHINYA TOKUNAGA AU - YOKO MIZUYAMA AU - TAKESHI SUNAMI AU - KENJI TEZUKA AU - KATSUMI IKEDA AU - YOSHINARI OGAWA AU - SHINICHIRO KASHIWAGI AU - SATORU NODA AU - NAOYOSHI ONODA AU - TETSURO ISHIKAWA AU - SHINZOH KUDOH AU - MINORU TAKADA AU - KOSEI HIRAKAWA AU - MASAICHI OHIRA Y1 - 2018/01/01 UR - http://ar.iiarjournals.org/content/38/1/379.abstract N2 - Background/Aim: Nab-paclitaxel (nab-PTX) is an albumin-bound paclitaxel formulation. Although nab-PTX has shown superior efficacy compared to conventional paclitaxel (PTX) in metastatic breast cancer (MBC), chemotherapy-induced peripheral neuropathy (CIPN) was more frequently observed in nab-PTX. In this study, we aimed to estimate the feasibility of the nab-PTX 175 mg/m2/3weeks regimen. Patients and Methods: Patients having metastatic or inoperable HER2-negative breast cancer received 175 mg/m2 of nab-PTX every three weeks. The primary endpoint was safety and the secondary endpoints were response and survival. Results: Seventeen patients were enrolled with a median age of 64 years. Ten patients had estrogen receptor positive disease and seven had triple-negative disease. CIPN was observed in seven patients (41%) however, grade 3 CIPN was only seen in one patient (6%). Objective response rate was 41% and progression-free survival was 23 weeks. Conclusion: Nab-PTX 175 mg/m2/3wks regimen has a good safety profile and less frequent CIPN. This regimen can contribute to the strategy of MBC treatment. ER -