RT Journal Article
SR Electronic
T1 MiRNA-210: A Current Overview
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6511
OP 6521
VO 37
IS 12
A1 ALBERTO BAVELLONI
A1 GIULIA RAMAZZOTTI
A1 ALESSANDRO POLI
A1 MANUELA PIAZZI
A1 ENRICO FOCACCIA
A1 WILLIAM BLALOCK
A1 IRENE FAENZA
YR 2017
UL http://ar.iiarjournals.org/content/37/12/6511.abstract
AB microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating evidence indicates that miRNAs contribute to tumorigenesis and cancer metastasis. microRNA-210 has been largely studied in the past several years and has been identified as a major miRNA induced under hypoxia. A variety of miR-210 targets have been identified pointing to its role, not only in mitochondrial metabolism, but also in angiogenesis, the DNA damage response, cell proliferation, and apoptosis. Based on earlier research findings, this review aims to provide a current overview on the involvement of miRNA-210 in biological processes and diseases.