PT  - JOURNAL ARTICLE
AU  - SENTO, SHINYA
AU  - KITAMURA, NAOYA
AU  - YAMAMOTO, TETSUYA
AU  - NAKASHIRO, KOICHI
AU  - HAMAKAWA, HIROYUKI
AU  - IBARAGI, SOICHIRO
AU  - SASAKI, AKIRA
AU  - TAKAMARU, NATSUMI
AU  - MIYAMOTO, YOJI
AU  - KODANI, ISAMU
AU  - RYOKE, KAZUO
AU  - MISHIMA, KATSUAKI
AU  - UEYAMA, YOSHIYA
AU - ORAL CANCER STUDY GROUP OF CHUGOKU-SHIKOKU
TI  - Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients
DP  - 2017 Dec 01
TA  - Anticancer Research
PG  - 6977--6981
VI  - 37
IP  - 12
4099  - http://ar.iiarjournals.org/content/37/12/6977.short
4100  - http://ar.iiarjournals.org/content/37/12/6977.full
SO  - Anticancer Res2017 Dec 01; 37
AB  - Background/Aim: To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Patients and Methods: Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. Results: The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Conclusion: Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases.