%0 Journal Article %A SHINTARO SHIBA %A NORIYUKI OKONOGI %A SHINGO KATO %A MASARU WAKATSUKI %A DAIJIRO KOBAYASHI %A HIROKI KIYOHARA %A TATSUYA OHNO %A KUMIKO KARASAWA %A TAKASHI NAKANO %A TADASHI KAMADA %T Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers %D 2017 %J Anticancer Research %P 5577-5583 %V 37 %N 10 %X Background/Aim: To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy. Patients and Methods: Data regarding patients with unresectable and isolated recurrent lymph node from gynecological cancer after definitive radiotherapy were analyzed. Total dose of C-ion RT was 48-57.6 Gy (RBE) in 12 or 16 fractions. Results: Sixteen patients received re-irradiation by C-ion RT were analyzed. Median follow-up was 37 months. Median tumor size was 27 mm. None developed Grade 1 or higher acute toxicities and Grade 3 or higher late toxicities. The 3-year overall survival, local control and disease-free survival rates after C-ion RT were 74%, 94% and 55%, respectively. Conclusion: Re-irradiation with C-ion RT for lymph node recurrence of gynecological cancers after definitive radiotherapy can be safe and effective. This result suggested that C-ion RT could be a curative treatment option for conventionally difficult-to-cure patients. %U https://ar.iiarjournals.org/content/anticanres/37/10/5577.full.pdf