RT Journal Article
SR Electronic
T1 Primary Urinary Tract Lymphoma: Rare but Aggressive
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6989
OP 6995
VO 37
IS 12
A1 LONTOS, KONSTANTINOS
A1 TSAGIANNI, ANASTASIA
A1 MSAOUEL, PAVLOS
A1 APPLEMAN, LEONARD JOSEPH
A1 NASIOUDIS, DIMITRIOS
YR 2017
UL http://ar.iiarjournals.org/content/37/12/6989.abstract
AB Background: Primary urinary tract lymphoma (PUTL) is an uncommon disease with only a few case reports in the literature. Materials and Methods: Information about 1,264 patients diagnosed between 1983 and 2013 with PUTL was extracted from the Surveillance, Epidemiology and End Results database. Kaplan–Meier curves and multivariable regression analysis were used to analyze the survival and identify prognostic factors. A comparison of nodal diffuse large B-cell lymphoma (DLBCL) with PUTL DLBCL was performed. In addition, we compared the characteristics of kidney and bladder lymphoma. Results: PUTL incidence was 1 case/1,000,000 people per year. DLBCL was found to be the predominant histology. Five-year overall survival and cancer-specific survival were 49% and 58%, respectively. DLBCL histology, male gender, stage III-IV disease, and advanced age were found to be poor prognostic factors. Surgery may be beneficial. Urinary tract DLBCL has a worse prognosis than nodal DLBCL. Conclusion: To our knowledge, this is the largest population-based study of PUTL in the literature. The survival of patients has not improved in the era of modern therapies therefore new treatments are needed.