PT - JOURNAL ARTICLE AU - MAGDALENA DZIEDZIC AU - IWONA SADOWSKA-KRAWCZENKO AU - JAN STYCZYNSKI TI - Risk Factors for Cytomegalovirus Infection After Allogeneic Hematopoietic Cell Transplantation in Malignancies: Proposal for Classification DP - 2017 Dec 01 TA - Anticancer Research PG - 6551--6556 VI - 37 IP - 12 4099 - http://ar.iiarjournals.org/content/37/12/6551.short 4100 - http://ar.iiarjournals.org/content/37/12/6551.full SO - Anticancer Res2017 Dec 01; 37 AB - Aim: To identify and classify risk factors for cytomegalovirus (CMV) infection and disease in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT), treated mainly for acute leukemia. Materials and Methods: A literature search was performed;eligible trials were clinical studies assessing the risk factors for CMV infection or disease in multivariate analysis. Results: Early reactivation in the setting of allo-HSCT took place mainly in patients without CMV prophylaxis, while late reactivation mainly in those patients who had completed previous prophylaxis or were on anti-CMV strategy based on pre-emptive prophylaxis. We propose classifying risk factors for CMV reactivation and CMV disease in patients after allo-HSCT as major and minor ones. Three major risk factors for CMV reactivation and CMV disease were found: (i) CMV-negative donor CMV-positive recipient serostatus, (ii) acute or chronic graft-versus-host disease, and (iii) unrelated or mismatched donor. Conclusion: CMV reactivation should be regarded as a continuous function of recipient and donor CMV-seropositivity and recipient immune suppression, caused by conditioning, immunosuppressive therapy and human leukocyte antigen disparity between donor and recipient.