TY - JOUR T1 - Differential Prognostic Value of Metabolic Heterogeneity of Primary Tumor and Metastatic Lymph Nodes in Patients with Pharyngeal Cancer JF - Anticancer Research JO - Anticancer Res SP - 5899 LP - 5905 VL - 37 IS - 10 AU - JEON YEOB JANG AU - KYOUNG JUNE PAK AU - KEUN-IK YI AU - YONG KAN KI AU - WON TAEK KIM AU - HYOJEONG KIM AU - YOUNG JIN CHOI AU - SEONG JANG KIM AU - IN JOO KIM AU - SOO-GEUN WANG AU - YOUNG MI SEOL Y1 - 2017/10/01 UR - http://ar.iiarjournals.org/content/37/10/5899.abstract N2 - Background/Aim: We aimed to explore the prognostic value of metabolic heterogeneity of 18F-FDG uptake in chemoradiotherapy-treated pharyngeal cancer patients. Patients and Methods: This study included 52 consecutive patients with pharyngeal cancer who underwent 18F-FDG PET/CT before definitive chemoradiotherapy. The heterogeneity factor (HF) was defined as the derivative (dV/dT) of a volume-threshold function for primary tumors and metastatic lymph nodes. The relationships between clinical parameters and HFs of primary tumors (pHF) and metastatic lymph nodes (nHF) were analyzed. Results: The pHF (range=∓1.367 - −0.027; median=−0.152) was significantly correlated with the maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis. Induction chemotherapy response was not correlated with HF, whereas response to radiotherapy was significantly better in patients with high pHF (low heterogeneity). Consistently, the 2-year locoregional recurrence-free survival was significantly better in patients with high pHF (82.9% for pHF>−0.152 vs. 30.5% for pHF<−0.152, log-rank p=0.009). The nHF (range=−1.067 - −0.039; median=-0.160) was not correlated with response to radiotherapy and locoregional recurrences. Conclusion: pHF, but not nHF, was a significant predictor of response to radiotherapy and locoregional recurrence in pharyngeal cancer. Thus, HF use can prevent unnecessary treatment and surgical delays. ER -