PT  - JOURNAL ARTICLE
AU  - AKI TAKIYAMA
AU  - TOSHIAKI TANAKA
AU  - YOKO YAMAMOTO
AU  - KEISUKE HATA
AU  - SOICHIRO ISHIHARA
AU  - HIROAKI NOZAWA
AU  - KAZUSHIGE KAWAI
AU  - TOMOMICHI KIYOMATSU
AU  - TAKESHI NISHIKAWA
AU  - KENSUKE OTANI
AU  - KAZUHITO SASAKI
AU  - TOSHIAKI WATANABE
TI  - Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms
DP  - 2017 Oct 01
TA  - Anticancer Research
PG  - 5785--5790
VI  - 37
IP  - 10
4099  - http://ar.iiarjournals.org/content/37/10/5785.short
4100  - http://ar.iiarjournals.org/content/37/10/5785.full
SO  - Anticancer Res2017 Oct 01; 37
AB  - Background/Aim: Few studies have evaluated the risk of postoperative colorectal neoplasms stratified by the nature of primary colorectal cancer (CRC). In this study, we revealed it on the basis of the microsatellite (MS) status of primary CRC. Materials and Methods: We retrospectively reviewed 338 patients with CRC and calculated the risk of neoplasms during postoperative surveillance colonoscopy in association with the MS status of primary CRC. A propensity score method was applied. Results: We identified a higher incidence of metachronous rectal neoplasms after the resection of MS stable CRC than MS instable CRC (adjusted HR 5.74, p=0.04). We also observed a higher incidence of colorectal tubular adenoma in patients with MSS CRC (adjusted hazard ratio 7.09, p<0.01) and a higher incidence of postoperative tubulovillous/villous adenoma in patients with MS instable CRC (adjusted HR=8.50, p=0.03). Conclusion: The MS status of primary colorectal cancer influenced the risk of postoperative colorectal neoplasms.