RT Journal Article
SR Electronic
T1 Inconsistent Reporting Between Meta-analysis Protocol and Publication – A Cross-Sectional Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5101
OP 5107
VO 37
IS 9
A1 ALBERTO FALK DELGADO
A1 ANNA FALK DELGADO
YR 2017
UL http://ar.iiarjournals.org/content/37/9/5101.abstract
AB Background: Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses. Materials and Methods: A cross-sectional study was performed including oncology drug meta-analyses published between January 1st and November 14th 2016 with a published protocol. Two investigators extracted data on: selection criteria, outcome(s) and statistical plan in protocol and manuscript, plus self-acknowledgement of inconsistent reporting between protocol and publication. Results: Protocol registration was present in 19% (23/119) of all oncology drug meta-analyses. In meta-analyses with protocol (n=23), 70% (16/23) had issues with inconsistent reporting between protocol and published report concerning; inclusion criteria, comparator group, intervention, outcome (PICO) or statistical analysis. Self-acknowledgement of changes between protocol and publication was found in 50% (8/16). Conclusion: In meta-analyses with protocol, discrepancies between registered protocols and publications are frequent.