RT Journal Article SR Electronic T1 Risk-reducing Salpingo–Oophorectomy in Women at Higher Risk of Ovarian and Breast Cancer: A Single Institution Prospective Series JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5241 OP 5248 VO 37 IS 9 A1 ENZO RICCIARDI A1 FEDERICA TOMAO A1 GIOVANNI ALETTI A1 LUCA BAZZURINI A1 LUCA BOCCIOLONE A1 SARA BOVERI A1 FABIO LANDONI A1 MARIA TERESA LAPRESA A1 MATTEO MARUCCIO A1 GABRIELLA PARMA A1 FEDRO PECCATORI A1 MARIA CRISTINA PETRELLA A1 VANNA ZANAGNOLO A1 NICOLETTA COLOMBO A1 ANGELO MAGGIONI YR 2017 UL http://ar.iiarjournals.org/content/37/9/5241.abstract AB Background/Aim: Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and occult invasive cancer and to evaluate the cancer-specific mortality in a prospective series of women at higher risk of ovarian and breast cancer undergoing risk-reducing salpingo-oophorectomy (RRSO) n a tertiary cancer center. Patients and Methods: A series of RRSO specimens (including endometrial biopsy) from women carrying a BRCA mutation, BRCA-unknown and BRCA-negative were collected between January 1998 and April 2016 at the Division of Gynecology at the European Institute of Oncology. Inclusion criteria were: asymptomatic women who had a negative gynecologic screening within 3 months prior to RRSO. Exclusion criteria were: women with ovarian/tubal cancer prior to RRSO. Results: A total of 411 women underwent RRSO. Median age at RRSO was 47.0 years (range=32–70 years); 75.2% had a history of breast cancer. Fifteen women were diagnosed with an occult cancer (7 STIC, 4 invasive cancers, 2 breast cancers metastatic to the adnexa, 2 endometrial cancer) (3.6%). Sixteen showed a STIL (3.9%). When excluding cases with preoperative positive markers, the occult invasive cancer rate drops to 1.5%. Conclusion: Our study, covering an 18-year period, shows a substantial low risk of occult cancer among a high-risk population of women undergoing RRSO. Our data still support the indication for RRSO in higher-risk patients. An endometrial biopsy should also be routinely obtained as it raises the chances of detecting occult endometrial cancers that may be otherwise missed.